Patients with overlap syndromes present with both hepatitic and cholestatic biochemical and histological features of AIH, PBC, and/or PSC, and usually show a progressive course toward liver ...

AIH, PBC, and PSC exhibit distinct cellular targets and inflammatory profiles, underlining the importance of personalized ...

There are three main ALDs: autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Symptoms of ALD vary among patients and can include non-specific ...

Autoimmune liver diseases (AILDs), such as autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), and primary biliary cholangitis (PBC), are classified as rare diseases, but their incidence ...

Unlike PSC, PBC does not increase the risk of cancer, but it can still cause serious liver disease if untreated. The main treatment is ursodeoxycholic acid (UDCA), which helps slow the disease and ...

Autoimmune hepatitis occurs when the immune system mistakenly attacks the liver. This sometimes leads to a form of PSC that can ... virus (HIV), and primary biliary cirrhosis (a chronic liver ...

Around 10% to 15% of people with PBC also have thyroid disease, especially Hashimoto's, and 5% to 15% develop rheumatoid arthritis and/or have limited cutaneous scleroderma. Autoimmune hepatitis ...

Semin Liver Dis. 2005;25(3):311-320. At present, it remains unclear whether AIH-PBC overlap syndromes represent (1) a hepatitic form of PBC determined by the genetic susceptibility of the patient ...

Hepatoblasts differentiate into hepatocytes, large and small cholangiocytes. CK8, CK18, and CK19 are expressed in hepatoblasts. CK8 and CK18 are expressed in hepatocytes at week 6. CK19 is ...