Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasion, self-renewal, ...

Because adenylate kinase is described as a crucial enzyme maintaining the pool sizes of various adenylates at equilibrium 13, it represents an interesting target for modulating the adenylate pools.

Insights into closed enzymes Date: June 27, 2017 Source: University of Konstanz Summary: Scientists have arrived at a structural model of the enzyme adenylate kinase in its closed state.

For the chemical reaction that forms ATP to take place, the building blocks AMP and ADP must be placed in precise geometry relative to each other in the active site of the enzyme adenylate kinase.