The 'resting' state may actually reflect a defined mode of an active cell. We therefore suggest that 'resting' microglia should be renamed 'surveying' microglia, as they actively search for and ...

As people age past 50, their brains begin to decrease in mass. But even as neurons shrink, other brain cells appear to become more active. Microglia -- the small immune cells that sense injury and ...

Every fortress needs watchmen, sentinels who don’t just sound the alarm, but sense when danger is approaching. For decades, we believed the brain’s sentinels were microglia alone, immune cells ...

A recent breakthrough by scientists at the University of California, San Francisco, offers a fresh and promising path toward ...

When microglia detect drugs such as opiates, cocaine or methamphetamine they release cytokines, which causes the neurons that are active at the time of drug-taking to become more excitable.

A specific active state of microglia that was associated with inflammation was identified. The scientists gave the mice xenon gas to inhale, which changed the state of their microglia.

Microglia in brain organoids derived from people with autism had larger cell bodies than cells from controls and had an overabundance of small cellular extensions associated with an active, ...

Microglia, the immune cells of the brain, ... The Brain’s Sculptors The discovery that microglia were active in the healthy brain jump-started the exploration into their underlying mechanisms: ...

Conversely, inhibiting ISR in microglia led to a reduction in these symptoms. The study highlights that ISR-active microglia promote the secretion of harmful lipids that negatively affect neuron ...

Using PET scans, researchers track the brain cells known as microglia, which remove and repair damaged neurons. Those cells are typically active after trauma, including concussions, and become ...