Pancreatic acinar cells show high plasticity and can undergo acinar-to-ductal metaplasia, which might be an initiating event for pancreatic cancer. Here, the determinants of acinar cell plasticity ...

Acinar cells are notoriously hard to culture long-term, and some mature acinar cells can transdifferentiate into ductal cells. To determine whether the organoid followed the same developmental ...

Acinar-derived insulin-producing (ADIP) cells infiltrate pre-existing endocrine islets. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-47972-4 ...

Natalie Cosgrove, MD, is a second year gastroenterology fellow at Thomas Jefferson University. She completed her undergraduate training at Bucknell University. She graduated with a medical degree ...

Estrogen-Related Receptor γ maintains pancreatic acinar cell function and identity by regulating cellular metabolism. Gastroenterology, 2022; DOI: 10.1053/j.gastro.2022.04.013; ...

This article is published in Cell Metabolism, in the article, “Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and ...

Biopsy suggested pancreatic acinar cell cancer; serum lipase was elevated to 4 times normal. How to manage the patient?

Scientists have known that, when the pancreas becomes inflamed, acinar cells, which produce digestive enzymes, begin to transform into ductal cells, which transport digestive juices in the pancreas.

The ductal cells responded by changing back to acinar cells. Pancreatic cancer can be prevented when acinar cells are maintained in their natural state. Related Stories.

Researchers were then able to label acinar cells in green and ductal cells, which channel saliva from the acinar cells into the mouse’s mouth, in pink. Credit: Noel Cruz-Pacheco ...

PURPOSE: Acinar cell carcinoma is a rare tumor of the exocrine pancreas. Clinical features such as prognostic information, survival, and treatment outcomes are unknown. We present the largest ...