However, SV-AUC was better than SEC-MALS in creating a detailed "map" of the distribution of the genetic and viral particles in the AAV vector. The study suggested that "SEC-MALS could be ...

An AAV sample with predominantly filled capsids ... without external standard curves. On the other hand, AUC separates particles based on their sedimentation rates, providing detailed physical ...

Gene therapy represents one of the fastest growing biotherapeutics worldwide, with AAV at the forefront. This rapid growth is constantly challenging CMC approaches, from manufacturing through release ...