Zhang Hong from the Institute of Biophysics of the Chinese Academy of Sciences has uncovered the molecular mechanism by which the key autophagy protein ATG-9 promotes the repair of damaged ...

Autophagy is one of the mechanisms through which cellular protein is degraded. Previously, it was known that Atg proteins assemble to form a structure called PAS(3). However, the mechanism through ...

Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic ... the addition of ATG5–ATG12 conjugates and ATG8 proteins (e.g., LC3-II) to become an autophagosome.

The formation of the autophagosome is controlled by an orderly action of ATG proteins. However, how these proteins are recruited to autophagic membranes remain poorly clarified. In this study ...

The team found that this process was dependent on a protein called ATG-16.2. The study identified several new functions for the autophagy protein ATG-16.2, including in exopher formation and life ...

In contrast, during microautophagy, proteins translocate directly into the lysosomes. Finally, in the case of chaperone-mediated autophagy, the degradation of proteins is enabled, harboring a ...

It is the name of a group of proteins involved in autophagy identified in yeast, and more than 40 have been reported to date. They are named roughly sequentially in the following formula: "Atg" + the ...

Autophagy is one of the mechanisms through which cellular protein is degraded. Previously, it was known that Atg proteins assemble to form a structure called PAS(3). However, the mechanism through ...