Using RNA sequencing databases of cancer patients, the researchers found that STAT3 and STAT5 work together to control the quantity of dendritic cells. Through transcriptional signaling, each protein ...

A common finding in inflammation-associated cancers is hyperactivation of signal transducer and activator of transcription 3 (STAT3) in various cell types, but the mechanisms linking inflammation ...

Mechanistically, NR2F1 directly interacts with the STAT3 promoter, resulting in its transcription. In turn, STAT3 promotes fibrosis and enhances lens epithelial cell migration and apoptosis ...