The authors of this study stated that even though ADAM10 and ADAM17 function at different phases of SARS-CoV-2 infection, both proteases function via proteolytic priming of the S protein.

They are required for the ADAM17 enzyme to function outside of a cell. Until now, these details have not been well understood. Seegar emphasized the human impact. “This work provides a foundation for ...

As structural studies revealed, iRhom2’s impact on ADAM17 function starts during the initial synthesis of the two proteins. “The endoplasmic reticulum is where ADAM17 and iRhom2 are made, and ...

Normally, ADAM17 sits as a pair of molecular scissors in the cell's outer membrane and cleaves other proteins from the cell surface - for example, growth factors that will then stimulate cell growth.

Results: HKH-2 cells showed enhanced sensitivity to 5-FU compared to HCT116 cells. Furthermore, oncogenic Kras was associated with increased Erk1/2 activity, ligand shedding and this correlated with ...