ADAM10 was critically involved in CD23 shedding in both gain-of-function and loss-of-function studies in MEFs, whereas ADAM33 was able to elicit shedding of CD23 only in the gain-of-function ...

ADAM10 regulates angiogenic events in human retinal microvascular endothelial cells (HRMVECs). Credit: The American Journal of Pathology (2025). DOI: 10.1016/j.ajpath.2025.03.007 ...

Not everyone was convinced that these mutations alter ADAM10 function. For instance, Rolf Postina and Elzbieta Kojro of Johannes Gutenberg University, Mainz, Germany, pointed out that the increase in ...

New research has found that the endothelial cell-specific A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) regulates abnormal blood vessel growth in the damaged retina ...

The authors of this study stated that even though ADAM10 and ADAM17 function at different phases of SARS-CoV-2 infection, both proteases function via proteolytic priming of the S protein.

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function. Neuron, 2013; DOI: 10.1016/j.neuron.2013.08.035 ...

09 Apr 2010 It was once All About Eve (check out the 1950s movie trailer). But what about Adam, or ADAM10, to be more precise? Unlike the glamorous but snarky Eve, this protease, thought to be the ...

A local study discovered a novel therapeutic target named ADAM10 that could be used to treat patients with Diabetic Retinopathy (DR), a condition which leads to blindness induced by prolonged ...

It seems that a drug that is actually approved for treatment of the dermal disorder psoriasis stimulates the activity of the enzyme ADAM10 in the brain of Alzheimer's patients. It is estimated ...

Philadelphia, June 24, 2025 – New research has found that the endothelial cell-specific A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) regulates abnormal blood vessel ...

While investigating how ADAM10 influences abnormal blood vessel growth, the researchers found that ADAM10 regulates the levels of the protein Ephrin B2 in endothelial cells, and decreasing Ephrin ...