When cortisol levels are low, the hypothalamus releases the corticotrophin-releasing hormone (CRH), which triggers the anterior pituitary gland to release the adrenocorticotropic hormone (ACTH).

ACTH insensitivity is a cardinal feature of ALD, but the mechanism is unknown. We studied a 10 year old hyperpigmented boy with glucocorticoid insufficiency of 8 years duration and a history of ...

The pituitary gland, located at the base of the brain, regulates cortisol through another hormone called Adrenocorticotropic Hormone (ACTH). Often referred to as the “stress hormone,” cortisol ...

These organoids imitate the pituitary gland’s functions, including the generation of adrenocorticotropic hormone (ACTH), which regulates stress, metabolism, blood pressure, and inflammation.