They apply the so-called 3R principle when planning and carrying out the experiments. '3R' stands for "Reduce, Refine, Replace": the number of animals per experiment is reduced to the absolute minimum ...

The specific tau isoforms, such as 3-repeat (3R) and 4-repeat (4R) isoforms, and the distinct conformational strains that misfolded tau can adopt are determinants of the molecular and clinical ...