We found that inclusion or exclusion of the 3′UTR of an mRNA that encodes a transcription factor did not change how much of the transcription factor protein was expressed but determined the location ...

Both need to be associated with (A+U)-rich elements in the 3′ untranslated region (UTR) of the TNF alpha mRNA. Now the researchers introduce a miRNA as the mediator of this interaction.

In mammals, they guide the RNA-induced silencing complex to target sites typically located in the 3′ untranslated regions (UTR) of mRNAs, causing translational repression and/or mRNA degradation 1.