Nitisinone, a drug that is already used to treat two genetic diseases, could be repurposed to control the spread of malaria, ...

Nitisinone was shown to last longer than ivermectin in the human bloodstream, and was able to kill not only mosquitoes of all ages—including the older ones that are most likely to transmit ...

Nitisinone blocks the enzyme 4-hydroxyphenylpyruvate dioxygenase in the body. "While this helps patients with metabolic disorders, it disrupts digestion in mosquitoes that drink the blood of ...

Nitisinone was shown to last longer than ivermectin in the human bloodstream, and was able to kill not only mosquitoes of all ages -- including the older ones that are most likely to transmit ...

But nitisinone offers distinct advantages, the researchers say. It works faster, sticks around longer in the bloodstream, and doesn’t target the nervous system.

Typically, nitisinone is a medication for individuals with rare inherited diseases - such as alkaptonuria and tyrosinemia type 1 - whose bodies struggle to metabolize the amino acid tyrosine.

Because nitisinone has already passed rigorous safety standards, repurposing the drug to combat mosquito-borne diseases would also require fewer approvals, says Acosta Serrano, ...

Nitisinone, a medication typically prescribed for individuals with rare inherited diseases, has been shown to make human blood deadly to mosquitoes. It could therefore be an alternative method for ...

In the past, ivermectin had been used to reach a similar solution by turning human blood into bug poison, but the scientists behind the study said that nitisinone has advantages over the other drugs.

BOSTON & CAMBRIDGE, England, June 19, 2025--Cycle Pharmaceuticals announced that the FDA has approved HARLIKU (nitisinone) Tablets for the reduction of urine homogentisic acid (HGA) in adult ...

Cycle Pharmaceuticals announced that the FDA has approved HARLIKU (nitisinone) Tablets for the reduction of urine homogentisic acid (HGA) in adult patients with AKU.1 The approval of HARLIKU is ...