Isenthal is a municipality in the canton of Uri in Switzerland. Isenthal is first mentioned in 1280 as Yseltal. Isenthal has an area, of 60.97 km². Of …Isenthal is a municipality in the canton of Uri in Switzerland. Isenthal is first mentioned in 1280 as Yseltal. Isenthal has an area, of 60.97 km². Of this area, about 28.0% is used for agricultural purposes, while 27.1% is forested. Of the rest of the land, 0.8% is settled and 44.0% is unproductive land. Over the past two decades the amount of land that is settled has increased by 17 ha and the agricultural land has decreased by 32 ha.